Winston-Salem police say parts of Highway 52 northbound and Interstate 40 westbound are closed in the area. Interstate 40 eastbound is open, but with a detour.
The North Carolina Department of Transportation says this may not clear until close to 10 a.m.
It happened on Highway 52 North, near Interstate 40, around 4:05 a.m.
Police say if residents see cattle roaming, please call the non-emergency hotline at 336-773-7700.
It is unknown what caused the tractor-trailer to overturn.
Multiple agencies are assisting in the effort to safely remove the cattle from the overturned tractor trailer, including Piedmont Emergency Animal Services. The highway is expected to be closed for a fewmore hours. #cityofwspolicepic.twitter.com/VC2wFsQLPN
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