Pfizer’s latest drug for migraines, Zavzpret (zavegepant), has been approved by the U.S. Food and Drug Administration.
This is the only migraine treatment that is offered in a nasal spray.
In clinical trials, the drug has been shown to provide quick pain relief in as little as 15 minutes for those who suffer from migraines, and the relief can last for up to 48 hours.
In studies previously released by Pfizer and reviewed by the FDA, zavegepant reduced moderate-to-severe headache pain two hours after people used the spray compared to those who squirted a placebo up their nose. Among those receiving the spray, 24% reported pain relief after two hours, compared to 15% of those getting placebo.
For some people getting the drug, relief began as soon as 15 minutes after they took the medication.
“With CGRP medications, scientists for the first time looked at the pathophysiology of migraine, or what was causing migraine, in order to understand how to modify and alter that process,” says Dr. Kathleen Mullin, associate medical director at New England Institute for Neurology and Headache, and an investigator on one of the zavegepant trials.
Experts believe that blocking the calcitonin gene-related peptide receptors in the brain reduces inflammation that is linked to migraine pain.
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