July 2, 2022
Vaccine mRNA Can Be Detected in Blood at 15 Days Post-Vaccination”
The biodistribution and pharmacokinetics of the mRNA-containing lipid nanoparticles (LNPs) in COVID vaccines are unknown in humans.
In this study, we used qPCR to track circulating mRNA in blood at different time-points after BNT162b2 vaccination in a small cohort of healthy individuals.
They found that vaccine-associated synthetic mRNA persists in systemic circulation for at least 2 weeks. Furthermore, we used transmission electron microscopy (TEM) to investigate SARS-CoV-2 spike protein expression in human leukemic cells and in primary mononuclear blood cells treated in vitro with the BNT162b2 vaccine.
TEM revealed morphological changes suggestive of LNP uptake, but only a small fraction of K562 leukemic cells presented spike-like structures at the cell surface, suggesting reduced levels of expression for these specific phenotypes.”
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