July 17, 2022
Neutralization Escape by SARS-CoV-2 Omicron Subvariants BA.2.12.1, BA.4, and BA.5
“In recent months, multiple lineages of the omicron (B.1.1.529) variant of SARS-CoV-2 have emerged, with subvariants BA.1 and BA.2 showing substantial escape from neutralizing antibodies. Subvariant BA.2.12.1 is now the dominant strain in the U.S., and BA.4 and BA.5 are dominant in South Africa.
We evaluated neutralizing antibody titers against the reference WA1/2020 isolate of SARS-CoV-2 along with omicron subvariants BA.1, BA.2, BA.2.12.1, and BA.4
BA.5 in 27 participants who had been vaccinated and boosted with mRNA BNT162b2 and in 27 participants who had been infected with the BA.1 or BA.2 subvariant.
Among the participants who had been infected with the BA.1 or BA.2 subvariant of omicron, all but one had been vaccinated against COVID-19.
These data show that the BA.2.12.1, BA.4, and BA.5 subvariants substantially escape neutralizing antibodies induced by both vaccination and infection”
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