9/8/2022
EU – Romanian MEP Cristian Terhes putting the questions we’d all like answers to, to Moderna and Pfizer officials over their secretive Covid contracts.
The Moderna and Pfizer bivalent boosters both target two strains of COVID-19 – the original strain of the virus and two of the Omicron variants (BA.4 and BA.5), the current most widespread variants in the world.
The independent board that conducted the interim analysis of Moderna’s huge trial found that severe side effects included fatigue in 9.7% of participants, muscle pain in 8.9%, joint pain in 5.2%, and headache in 4.5%.
Note: Both Moderna’s and Pfizer/BioNTech’s vaccines require two doses separated by several weeks. Reactogenicity is typically higher after a second dose, Weissman says.
The side effects “mean the vaccine is working well. … [It] means you had such a good immune response to the first dose and now you are seeing the effects of that,” he says.
“We suspect the lipid nanoparticle causes the reactogenicity, because lipid nanoparticles without mRNA in them do the same thing in animals,” Weissman says.
“We see production, in the muscle, of inflammatory mediators that cause pain, [redness], swelling, fever, flulike symptoms, etc.”
(Weissman co-invented the mRNA modifications that both Moderna and BioNTech have licensed to make their vaccines, and he receives royalties from the companies.)
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