A new study finds a chemical formed when we digest a widely used sweetener is “genotoxic,” meaning it breaks up DNA.
The chemical is also found in trace amounts in the sweetener itself, and the finding raises questions about how the sweetener may contribute to health problems.
“To put this in context, the European Food Safety Authority has a threshold of toxicological concern for all genotoxic substances of 0.15 micrograms per person per day,” Schiffman says.
“Our work suggests that the trace amounts of sucralose-6-acetate in a single, daily sucralose-sweetened drink exceed that threshold.
And that’s not even accounting for the amount of sucralose-6-acetate produced as metabolites after people consume sucralose.”
For the study, researchers conducted a series of in vitro experiments exposing human blood cells to sucralose-6-acetate and monitoring for markers of genotoxicity.
“In short, we found that sucralose-6-acetate is genotoxic, and that it effectively broke up DNA in cells that were exposed to the chemical,” Schiffman says.
The researchers also conducted in vitro tests that exposed human gut tissues to sucralose-6-acetate.
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