A Device smaller than grain of rice successfully shrinks pancreatic cancer – one of the most aggressive forms of cancer
Houston Methodist nanomedicine researchers have found a way to tame pancreatic cancer – one of the most aggressive and difficult to treat cancers – by delivering immunotherapy directly into the tumor with a device that is smaller than a grain of rice.
In a paper recently published in Advanced Science, Houston Methodist Research Institute researchers used an implantable nanofluidic device they invented to deliver CD40 monoclonal antibodies (mAb), a promising immunotherapeutic agent, at a sustained low-dose via the nanofluidic drug-eluting seed (NDES).
The result, found in murine models, was tumor reduction at a fourfold lower dosage than traditional systemic immunotherapy treatment.
“This means that local treatment with immunotherapy was able to activate the immune response to target other tumors.
In fact, one animal model remained tumor-free for the 100-days of continued observation.”
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