1/6/2023
The first step for workers in this suburban Minneapolis lab is to shampoo away the pig cells that made the organ do its work, its color gradually fading as the cells dissolve and are flushed out. What’s left is a rubbery scaffolding, a honeycomb structure of the liver, its blood vessels now empty.
Next human liver cells — taken from donated organs unable to be transplanted — will be oozed back inside that shell. Those living cells move into the scaffolding’s nooks and crannies to restart the organ’s functions.
“We essentially regrow the organ,” said Jeff Ross, CEO of Miromatrix. “Our bodies won’t see it as a pig organ anymore.”
That’s a bold claim. Sometime in 2023, Miromatrix plans first-of-its-kind human testing of a bioengineered organ to start trying to prove it.
If the Food and Drug Administration agrees, the initial experiment will be outside a patient’s body. Researchers would place a pig-turned-humanlike liver next to a hospital bed to temporarily filter the blood of someone whose own liver suddenly failed.
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