A 44-year-old woman, shot in the face and back about 3:30 a.m., was rushed by medics to Harlem Hospital but could not be saved.
Also wounded: a 31-year-old woman, who was shot in the lower back, and a 32-year-old man, who was shot in the throat.
Both men are expected to survive.
Anyone with information is asked to call Crime Stoppers at 1-800-577-TIPS.