Shots were fired around 8:30 p.m. on the first block of 15th Street, according to police. Police said two men died of their injuries at a hospital.
A woman was also found injured at the scene, and a man and a woman were later hospitalized with injuries.
The condition of the woman found at the scene is unclear.
The man and woman who arrived at the hospital later suffered non-life-threatening wounds, according to police.
Harrisburg has recorded 10 homicides in light of Tuesday’s shooting.
Police have not announced any arrests as of Wednesday morning. They are asking anyone with information to call 717-558-6900 or submit a tip through CrimeWatch.
